Chronic transcranial focal stimulation from tripolar concentric ring electrodes does not disrupt memory formation in rats
Document Type
Conference Proceeding
Date of Original Version
11-2-2014
Abstract
Non-invasive electrical brain stimulation has shown potential utility as a treatment for seizures in epilepsy patients. Transcranial focal stimulation (TFS) via tripolar concentric ring electrodes (TCREs) has been effective in reducing seizure severity in acute rodent models, but it has yet to be determined whether or not it will serve as a viable long-term treatment strategy. Prior experiments indicate that a single dose of TFS via TCRE does not impact short- or long-term memory formation. The present study investigated if five daily doses of TFS via a TCRE on the scalp affected the memory. The spontaneous object recognition (SOR) test was used to evaluate the memory. Sham and TFS-treated groups were evaluated and both showed comparable levels of preference for novel objects, indicating successful memory formation. More work on repeated dosage strategies is important for establishing the safety and efficacy of TFS as a putative treatment.
Publication Title, e.g., Journal
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Embc 2014
Citation/Publisher Attribution
Luby, Matthew D., Oleksandr Makeyev, and Walter G. Besio. "Chronic transcranial focal stimulation from tripolar concentric ring electrodes does not disrupt memory formation in rats." 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Embc 2014 (2014). doi: 10.1109/EMBC.2014.6945030.