Recent advances in the discovery of Src kinase inhibitors

Authors

Keykavous Parang, University of Rhode Island
Gongqin Sun, University of Rhode Island

Document Type

Article

Date of Original Version

9-1-2005

Abstract

Src family kinases are involved in the regulation of a wide variety of normal cellular signal transduction pathways, such as cell growth, differentiation, survival, adhesion and migration. Considerable evidence implicates elevated expression and/or activity of Src kinases in many human cancers, osteoporosis, cardiovascular disorders and immune system dysfunction; thus, this family of protein tyrosine kinases now exists as intriguing targets for both basic research and drug discovery. Herein, a number of examples of currently developed Src family kinase inhibitors in selected patents from 2002 - 2005 will be described. Special attention will be made to the chemical diversity of ATP binding site inhibitors, potency, selectivity and therapeutic application of the compounds. © 2005 Ashley Publications Ltd.

Publication Title, e.g., Journal

Expert Opinion on Therapeutic Patents

Volume

15

Issue

9

Citation/Publisher Attribution

Parang, Keykavous, and Gongqin Sun. "Recent advances in the discovery of Src kinase inhibitors." Expert Opinion on Therapeutic Patents 15, 9 (2005). doi: 10.1517/13543776.15.9.1183.