Durable changes in the gut microbiome in survivors of childhood acute lymphoblastic leukemia

Authors

Roma Bhuta, The Warren Alpert Medical School
Bradley DeNardo, The Warren Alpert Medical School
Jing Wang, University of Rhode Island
Janet Atoyan, University of Rhode Island
Ying Zhang, University of Rhode Island
David Nelson, University of Rhode Island
Jason Shapiro, The Warren Alpert Medical School

Document Type

Article

Date of Original Version

12-1-2021

Abstract

There are limiteddata on long-term changes in the gut microbiome after acute lymphoblastic leukemia (ALL) therapy. We compared the gut microbial composition in stool samples of nine survivors of childhood ALL with 10 healthy sibling controls using 16S rRNA gene sequencing. Analysis of beta diversity within family units demonstrated a significant difference in bacterial strains between patients and healthy siblings. A significant difference in alpha diversity between patients and their healthy siblings was noted using Pielou's evenness. The composition of the gut microbiome differs between pediatric ALL survivors and healthy sibling controls for years after completion of therapy.

Publication Title, e.g., Journal

Pediatric Blood and Cancer

Volume

68

Issue

12

Citation/Publisher Attribution

Bhuta, Roma, Bradley DeNardo, Jing Wang, Janet Atoyan, Ying Zhang, David Nelson, and Jason Shapiro. "Durable changes in the gut microbiome in survivors of childhood acute lymphoblastic leukemia." Pediatric Blood and Cancer 68, 12 (2021). doi: 10.1002/pbc.29308.