Regioselective gold-catalyzed oxidative C-N bond formation
Date of Original Version
A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.
Marchetti, Louis, Abhishek Kantak, Riley Davis, and Brenton Deboef. "Regioselective gold-catalyzed oxidative C-N bond formation." Organic Letters 17, 2 (2015): 358-361. doi:10.1021/ol5034805.