Title

Regioselective gold-catalyzed oxidative C-N bond formation

Document Type

Article

Date of Original Version

1-16-2015

Abstract

A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.

Publication Title

Organic Letters

Volume

17

Issue

2

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