Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents
Date of Original Version
Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced 129Xe MR spectroscopy.
Hane, Francis T., Ashvin Fernando, Braedan R.J. Prete, Brianna Peloquin, Scott Karas, Sauradip Chaudhuri, Simrun Chahal, Yurii Shepelytskyi, Alanna Wade, Tao Li, Brenton Deboef, and Mitchell S. Albert. "Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents." ACS Omega 3, 1 (2018): 677-681. doi:10.1021/acsomega.7b01744.