Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents

Authors

Francis T. Hane, Lakehead University
Ashvin Fernando, University of Rhode Island
Braedan R.J. Prete, Lakehead University
Brianna Peloquin, University of Rhode Island
Scott Karas, University of Rhode Island
Sauradip Chaudhuri, University of Rhode Island
Simrun Chahal, Lakehead University
Yurii Shepelytskyi, Lakehead University
Alanna Wade, Lakehead University
Tao Li, Lakehead University
Brenton Deboef, University of Rhode IslandFollow
Mitchell S. Albert, Lakehead University

Document Type

Article

Date of Original Version

1-31-2018

Abstract

Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced 129Xe MR spectroscopy.

Publication Title, e.g., Journal

ACS Omega

Volume

3

Issue

1

Citation/Publisher Attribution

Hane, Francis T., Ashvin Fernando, Braedan R.J. Prete, Brianna Peloquin, Scott Karas, Sauradip Chaudhuri, Simrun Chahal, Yurii Shepelytskyi, Alanna Wade, Tao Li, Brenton Deboef, and Mitchell S. Albert. "Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents." ACS Omega 3, 1 (2018): 677-681. doi: 10.1021/acsomega.7b01744.