HyperCEST detection of cucurbituril in whole blood using an ultrashort saturation Pre-pulse train
Date of Original Version
Xenon based biosensors have the potential to detect and localize biomarkers associated with a wide variety of diseases. The development and nuclear magnetic resonance (NMR) characterization of cage molecules which encapsulate hyperpolarized xenon is imperative for the development of these xenon biosensors. We acquired 129Xe NMR spectra, and magnetic resonance images and a HyperCEST saturation map of cucurbituril (CB6) in whole bovine blood. We observed a mean HyperCEST depletion of 84% (n = 5) at a concentration of 5 mM and 74% at 2.5 mM. Additionally, we collected these data using a pulsed HyperCEST saturation pre-pulse train with a SAR of 0.025 W/kg which will minimize any potential RF heating in animal or human tissue. Copyright © 2016 John Wiley & Sons, Ltd.
Contrast Media and Molecular Imaging
Hane, Francis T., Peter S. Smylie, Tao Li, Julia Ruberto, Krista Dowhos, Iain Ball, Boguslaw Tomanek, Brenton DeBoef, and Mitchell S. Albert. "HyperCEST detection of cucurbituril in whole blood using an ultrashort saturation Pre-pulse train." Contrast Media and Molecular Imaging 11, 4 (2016): 285-290. doi:10.1002/cmmi.1690.