HyperCEST detection of cucurbit[6]uril in whole blood using an ultrashort saturation Pre-pulse train
Document Type
Article
Date of Original Version
7-1-2016
Abstract
Xenon based biosensors have the potential to detect and localize biomarkers associated with a wide variety of diseases. The development and nuclear magnetic resonance (NMR) characterization of cage molecules which encapsulate hyperpolarized xenon is imperative for the development of these xenon biosensors. We acquired 129Xe NMR spectra, and magnetic resonance images and a HyperCEST saturation map of cucurbit[6]uril (CB6) in whole bovine blood. We observed a mean HyperCEST depletion of 84% (n = 5) at a concentration of 5 mM and 74% at 2.5 mM. Additionally, we collected these data using a pulsed HyperCEST saturation pre-pulse train with a SAR of 0.025 W/kg which will minimize any potential RF heating in animal or human tissue. Copyright © 2016 John Wiley & Sons, Ltd.
Publication Title, e.g., Journal
Contrast Media and Molecular Imaging
Volume
11
Issue
4
Citation/Publisher Attribution
Hane, Francis T., Peter S. Smylie, Tao Li, Julia Ruberto, Krista Dowhos, Iain Ball, Boguslaw Tomanek, Brenton DeBoef, and Mitchell S. Albert. "HyperCEST detection of cucurbit[6]uril in whole blood using an ultrashort saturation Pre-pulse train." Contrast Media and Molecular Imaging 11, 4 (2016): 285-290. doi: 10.1002/cmmi.1690.