Document Type
Article
Date of Original Version
2013
Abstract
Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one ‘enantiomer’ of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the ‘enantiomeric’ polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.
[Refer to PDF for graphical abstract]
Citation/Publisher Attribution
Gharavi, J., Marks, P., Moran, K., Kingsborough, B., Verma, R., Chen, Y., Deng, R., & Levine, M. (2013). Chiral cationic polyamines for chiral microcapsules and siRNA delivery. Bioorganic & Medicinal Chemistry Letters, 23(21), 5919-5922. doi: 10.1016/j.bmcl.2013.08.083
Available at: https://doi.org/10.1016/j.bmcl.2013.08.083
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comment
Justin Gharavi, Patrick Marks, Kelly Moran, Brett Kingsborough and Mindy Levine are in the Department of Chemistry.
Ruchi Verma, Yuan Chen and Ruitang Deng are in the Department of Biomedical and Pharmaceutical Sciences.
Author Manuscript
This is a pre-publication author manuscript of the final, published article.