Date of Original Version
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivodetection of the cucurbituril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.
Hane, F.T. et. al. In vivo detection of cucurbituril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor (2017) Scientific Reports 7(41027) doi: 10.1038/srep41027
Available at: http://dx.doi.org/10.1038/srep41027
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