In Vivo Detection of Cucurbit[6]uril, a Hyperpolarized Xenon Contrast Agent for a Xenon Magnetic Resonance Imaging Biosensor

Authors

Francis T. Hane
Tao Li
Peter Smylie
Raiili M. Pellizzari
Jennifer A. Plata
Brenton DeBoef, University of Rhode IslandFollow
Mitchell S. Albert

Document Type

Article

Date of Original Version

1-20-2017

Department

Chemistry

Abstract

The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivodetection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.

Citation/Publisher Attribution

Hane, F.T. et. al. In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor (2017) Scientific Reports 7(41027) doi: 10.1038/srep41027

Available at: http://dx.doi.org/10.1038/srep41027

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.