Document Type
Article
Date of Original Version
1-20-2017
Department
Chemistry
Abstract
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivodetection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.
Citation/Publisher Attribution
Hane, F.T. et. al. In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor (2017) Scientific Reports 7(41027) doi: 10.1038/srep41027
Available at: http://dx.doi.org/10.1038/srep41027
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.