Document Type
Article
Date of Original Version
2018
Department
Chemistry
Abstract
The detection of phthalates in human biologic fluids remains an important research objective because it provides an important measure of an individual’s exposure to this class of compounds, which have known deleterious health effects. Moreover, the ability to accomplish such detection in fluids that are easy to collect, such as saliva and urine, provides additional practical advantages. Reported herein is the application of cyclodextrin-promoted fluorescence energy transfer and fluorescence modulation to accomplish precisely such detection: the development of sensitive and selective florescence-based detection methods for phthalates in saliva, an easily collectable human biologic fluid. Such saliva-based detection methods occur with high levels of selectivity (100% differentiation) and sensitivity (limits of detection as low as 0.089 µM), and provide significant potential in the development of practical phthalate detection devices.
Citation/Publisher Attribution
Dana J. DiScenza, Melissa A. Smith, Lauren E. Intravaia & Mindy Levine (2018) Efficient Detection of Phthalate Esters in Human Saliva via Fluorescence Spectroscopy, Analytical Letters, DOI: 10.1080/00032719.2018.1471086
Available at: http://dx.doi.org/10.1080/00032719.2018.1471086
Author Manuscript
This is a pre-publication author manuscript of the final, published article.
Terms of Use
This article is made available under the terms and conditions applicable
towards Open Access Policy Articles, as set forth in our Terms of Use.