Document Type

Article

Date of Original Version

12-12-2017

Abstract

We have previously developed a highly efficient fluorescence-based toxicant-detection method that operates in complex environments to detect aromatic toxicants and toxicant metabolites with high sensitivity and selectivity. This method relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold, and uses a variety of non-covalent interactions between the cyclodextrin, toxicant, and fluorophore to enable efficient detection. Reported herein is an investigation of the effect of various experimental parameters, including host concentration, temperature, pH, salt, and solvent, on the observed energy-transfer efficiencies. These results advance our understanding of γ-cyclodextrin-based association complexes and provide crucial information for the development of fluorescence-based sensors using such complexation and the resultant fluorescence-based detection.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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