Modelling Liver Preservation
Document Type
Article
Date of Original Version
1-1-2024
Abstract
Liver preservation has obvious healthcare implications in treating liver diseases. With the continuing shortage of viable livers and other organs for transplantation, methods of organ preservation have progressed over the last 40 years from static cold storage to include machine perfusion in many clinical settings. However, modelling organ preservation has been slow to be accepted by the medical community. The objective of this paper is to present an overview of a novel approach to metabolic network modelling based on Nash equilibrium. An example of liver preservation consisting of static cold storage followed by machine perfusion is described. Monte Carlo (MC) optimization of the perfusion chamber temperature protocol and antioxidant supplementation for controlling the effects of reactive oxygen species (ROS) from reperfusion are also presented. Results show that the Nash equilibrium/Monte Carlo approach can predict fluxes, concentrations, pH, temperature policies, supplementation protocols, and other properties of a complex metabolic network.
Publication Title, e.g., Journal
Computer Aided Chemical Engineering
Volume
53
Citation/Publisher Attribution
Lucia, Angelo, and Korkut Uygun. "Modelling Liver Preservation." Computer Aided Chemical Engineering 53, (2024). doi: 10.1016/B978-0-443-28824-1.50407-5.