Microwave assisted vacuum drying and endpoint determination using mass spectrometry, part II, on-line moisture content profiling

Authors

Kevin Hettenbach, Pfizer Global Research and Development
David J. Am Ende, Pfizer Global Research and Development
Eric Dias, Pfizer Global Research and Development
Steven J. Brenek, Pfizer Global Research and Development
Catherine Laforte, Pfizer Global Research and Development
Stanley M. Barnett, University of Rhode Island

Document Type

Article

Date of Original Version

11-1-2004

Abstract

Quantitative methods were developed to compute on-line conventional loss-on-drying (LOD) profiles from mass spectrometry (MS) measurements. Good agreement between calculated LOD values and actual LOD measurements were obtained for single and multiple solvent wet cakes. Characteristic drying curve profiles were determined for calcium carbonate, sand, cellulose, starch, and silica gel solids, and the corresponding critical moisture contents were estimated. Although this work was developed for microwave drying, the methods apply to conventional dryer monitoring as well.

Publication Title, e.g., Journal

Organic Process Research and Development

Volume

8

Issue

6

Citation/Publisher Attribution

Hettenbach, Kevin, David J. Am Ende, Eric Dias, Steven J. Brenek, Catherine Laforte, and Stanley M. Barnett. "Microwave assisted vacuum drying and endpoint determination using mass spectrometry, part II, on-line moisture content profiling." Organic Process Research and Development 8, 6 (2004): 867-872. doi: 10.1021/op049853s.