A Nash Equilibrium approach to metabolic network analysis
Document Type
Conference Proceeding
Date of Original Version
1-1-2016
Abstract
A novel approach to metabolic network analysis using a Nash Equilibrium formulation is proposed. Enzymes are considered to be players in a multi-player game in which each player attempts to minimize the dimensionless Gibbs free energy associated with the biochemical reaction(s) it catalyzes subject to elemental mass balances. Mathematical formulation of the metabolic network as a set of nonlinear programming (NLP) sub-problems and appropriate solution methodologies are described. A small example representing part of the production cycle for acetyl-CoA is used to demonstrate the efficacy of the proposed Nash Equilibrium framework and show that it represents a paradigm shift in metabolic network analysis.
Publication Title, e.g., Journal
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume
10122 LNCS
Citation/Publisher Attribution
Lucia, Angelo, and Peter A. Dimaggio. "A Nash Equilibrium approach to metabolic network analysis." Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 10122 LNCS, (2016): 45-58. doi: 10.1007/978-3-319-51469-7_4.