Location
Cherry Auditorium, Kirk Hall
Start Date
4-5-2012 1:00 PM
Description
Crystallization is vital to many processes occurring in nature and manufacturing. In chemical, pharmaceutical and food industries, crystallization from solution is widely used for a variety of materials. It is an attractive isolation step during manufacturing as particle formation and purification are combined within a single process. Almost all of the products based on fine chemicals, such as dyes, explosives and photographic materials, require crystallization in their manufacture and over 90% of all pharmaceutical products contain bioactive drug substances and excipients in the crystalline solid state. Hence it is necessary to control the crystallization process in order to obtain products with desired and reproducible properties. The quality of a crystalline product is usually judged by four main properties: size, purity, morphology (shape) and crystal structure. It is vital in pharmaceutical industry to produce the desired crystal form (polymorph) to assure the bioavailability and stability of the drug substance. It is also important to produce the desired particle shape and size distribution to allow mixing of API with excipient and the formation of the final drug product.
Nucleation is the first step of the crystallization process and control of nucleation is crucial in forming crystals of the desired properties. In this talk the use of surfaces to template nucleation for the control of size, shape, and crystal form will be discussed.
Templated Nucleation of Organic Molecular Crystals on Surfaces
Cherry Auditorium, Kirk Hall
Crystallization is vital to many processes occurring in nature and manufacturing. In chemical, pharmaceutical and food industries, crystallization from solution is widely used for a variety of materials. It is an attractive isolation step during manufacturing as particle formation and purification are combined within a single process. Almost all of the products based on fine chemicals, such as dyes, explosives and photographic materials, require crystallization in their manufacture and over 90% of all pharmaceutical products contain bioactive drug substances and excipients in the crystalline solid state. Hence it is necessary to control the crystallization process in order to obtain products with desired and reproducible properties. The quality of a crystalline product is usually judged by four main properties: size, purity, morphology (shape) and crystal structure. It is vital in pharmaceutical industry to produce the desired crystal form (polymorph) to assure the bioavailability and stability of the drug substance. It is also important to produce the desired particle shape and size distribution to allow mixing of API with excipient and the formation of the final drug product.
Nucleation is the first step of the crystallization process and control of nucleation is crucial in forming crystals of the desired properties. In this talk the use of surfaces to template nucleation for the control of size, shape, and crystal form will be discussed.
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