Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η⁶-p-cymene)Ru(NS)Cl]⁺ (NS = 9-anthraldehyde thiosemicarbazones)

Authors

Floyd A. Beckford
Gabriel Leblanc
Jeffrey Thessing
Michael Shaloski Jr.
Brian J. Frost
Liya Li, University of Rhode Island
Navindra P. Seeram, University of Rhode IslandFollow

Document Type

Article

Date of Original Version

2009

Department

Biomedical and Pharmaceutical Sciences

Abstract

A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC = 9-anthraldehyde thiosemicarbazone and R = H, CH₃ and C₆H₅). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene–ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.

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Citation/Publisher Attribution

Beckford, F. A., Leblanc, G., Thessing, J., Shaloski, M., Jr., Frost, B. J., Li, L., & Seeram, N. P. (2009). Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η⁶-p-cymene)Ru(NS)Cl]⁺ (NS = 9-anthraldehyde thiosemicarbazones). Inorganic Chemistry Communications, 12(11), 1094-1098. doi: 10.1016/j.inoche.2009.08.034

Available at: https://doi.org/10.1016/j.inoche.2009.08.034

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