Date of Award

2015

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Brenton DeBoef

Abstract

The formation of carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds is discussed and efforts towards expanding the known reactions of this type are the primary focus of this work. The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes and furans has been achieved. The use of an imine directing group allowed for the ortho-functionalization of these heterocycles with complete conversation in 15 minutes at °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. C-N bond formation is achieved using aryl Grignard reagents and N-chloroamines at -78 °C.

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