Date of Award
Doctor of Philosophy in Pharmaceutical Sciences
Pharmacy and Toxicology
Pharmacology and Toxicology
George C. Fuller
Phenobarbital pretreatment significantly enhanced the risk in SGOT and SGPT immediately following a three-hour exposure of rats to carbon tetrachloride by inhalation. However, these parameters of hepatoxicity were significantly lower in rats pretreated with 3-methylcholenthrone when comapared to rats pretreated with vehicle and exposed to carbon tetrachloride vapor. Levels of hepatic microsomal NADPH cytochrome c reductase and CO-binding pigment were elevated by phenobarbital pretreatment, but with 3-methylcholenthrone had no effect on hepatic microsomal NADPH cytochrome c reductase.
Suarez, Kenneth Alfred, "The Effect of Modifiers of Microsomal Electron Transport On Carbon Tetrachloride Hepatoxicity" (1972). Open Access Dissertations. Paper 167.