Date of Award

1972

Degree Type

Dissertation

Degree Name

Doctor of Pharmacy (PharmD)

First Advisor

George C. Fuller

Abstract

Phenobarbital pretreatment significantly enhanced the risk in SGOT and SGPT immediately following a three-hour exposure of rats to carbon tetrachloride by inhalation. However, these parameters of hepatoxicity were significantly lower in rats pretreated with 3-methylcholenthrone when comapared to rats pretreated with vehicle and exposed to carbon tetrachloride vapor. Levels of hepatic microsomal NADPH cytochrome c reductase and CO-binding pigment were elevated by phenobarbital pretreatment, but with 3-methylcholenthrone had no effect on hepatic microsomal NADPH cytochrome c reductase.

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