Date of Award

1972

Degree Type

Dissertation

Degree Name

Doctor of Pharmacy (PharmD)

First Advisor

Harbans Lal

Abstract

The mechanisms whereby pargyline, succinic acid and absorbic acid protect against hyperbaric oxygen convulsions, pulmonary damage and mortality following hyperbaric oxygen exposure were investigated in relation to the effects of these agents on hyperbaric oxygen-induced alterations in brain gamma-aminobutyric acid and ammonia metabolism. Exposure to hyperbaric oxygen (60 pounds per square inch, gauge pressure) produced convulsions, post-exposure lethality and elevation in lung weight, lung water content and lung hemoglobin content. Pargyline, succinic acid and ascorbic acid provided partial production against all of the above aspects of toxicity.

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