Date of Award
Doctor of Pharmacy (PharmD)
The mechanisms whereby pargyline, succinic acid and absorbic acid protect against hyperbaric oxygen convulsions, pulmonary damage and mortality following hyperbaric oxygen exposure were investigated in relation to the effects of these agents on hyperbaric oxygen-induced alterations in brain gamma-aminobutyric acid and ammonia metabolism. Exposure to hyperbaric oxygen (60 pounds per square inch, gauge pressure) produced convulsions, post-exposure lethality and elevation in lung weight, lung water content and lung hemoglobin content. Pargyline, succinic acid and ascorbic acid provided partial production against all of the above aspects of toxicity.
Schatz, Robert Alfred, "PARGYLINE, SUCCINIC ACID AND L-ASCORBIC ACID AS PROTECTIVE AGENTS AGAINST HYPERBARIC OXYGEN TOXICITY: POSSIBLE INVOLVEMENT OF ALTERED GAMMA-AMINOBUTYRIC ACID AND AMMONIA METABOLISM" (1972). Open Access Dissertations. Paper 164.