Date of Award
Master of Science in Pharmacology
John J. DeFeo
The trans-2-o-tolyl, trans-2-p-tolyl and cis-2-p-tolyl derivatives of cyclohexamine hydrochloride and six other cyclohexane derivatives were tested for their effects on intact anesthetized rats, isolated rat atria, isolated guinea pig hearts, isolated guinea pig intestines and intact anesthetized cats. Most of these compounds produced effects on the cardiovascular system and on the small intestine in varying degrees.
Trans-2-o-tolylcyclohexamine hydrochloride was the most potent of the cyclohexamine series tested. Of the six other compounds tested, 2-o-tolylcyclohexen-2-one ($204) was the most potent in its cardiovascular effects.
Studies indicate that trans-2-o-tolylcyclohexylamine hydrochloride does not produce toxic effects in doses which ellicit its cardiovascular actions.
Smith, John Charles, "The Comparative Cardiovascular Effects of Substituted Cyclohexane Derivatives" (1963). Open Access Master's Theses. Paper 920.