Kiran Penumatcha, University of Rhode Island


The aim of present study was to prepare controlled release trazodone hydrochloride matrix tablets. The dissolution profiles at three pHs were carried out for 24 hrs to monitor release of drug from tablets. The effect of three variables, drug, HPMC, and A vicel contents, on the release of drug from the matrix was evaluated using a full 23 factorial design. T 50 and T 90 (time to release 50% and 90% drug respectively) were used as response parameters to study the effect of three variables mentioned above.The effect of tablet size was also studied by comparing the release from matrix-mini tablets and matrix tablet, which were made from the same formulation contents. The effect of three variables on the release of drug from the matrix was more evident on T 90 rather than T 50. The percentage of drug release was slower at higher level of drug and HPMC and lower level of Avicel. Among the three variables, the amount of drug has significant effect on drug release. Even though drug release from the matrix tablets was closer to zero-order, 100% of the drug was not released completely. Matrix tablets have longer T50 and T90 compared to matrix-mini tablets. The experimental design was shown to b e very useful in determining the direction for further optimization in order to achieve zero-order release.