Date of Award

1987

Degree Type

Thesis

Degree Name

Master of Science in Pharmacy

Department

Pharmacy

First Advisor

Joan Lausier

Abstract

A number of potential anticancer compounds exhibit solubility and stability problems (1,2). This study examined the solubility of AZQ (NSC-1 82986) in water and various solvent systems, with the following aims: 1. To expand knowledge of the physical and chemical properties of AZQ, and 2. To serve as a valuable preformulation compilation of data to identify solvents which enhance the solubility of AZQ, and have potential for human use. In this study, a rapid, simple, selective, and sensitive stability-indicating high-performance liquid chromatographic (HPLC) assay was developed for the simultaneous identification and quantification of AZQ. Of all the solvents tested, the solubility of AZQ in dimethylacetamide (OMA) was the best, followed by ethanol 95% and other lipid solvents. Phosphate buffer, at pH = 6.5, was a good solvent as compared to plain distilled water in that degradation was reduced. The effects of temperature were also studied. It was very clear from the results obtained that raising the incubation temperature from 25°C to 40°C led to the decline in the solubility of AZQ in phosphate buffer, water and peanut oil as solvents. Optimum temperature for maximum solubility was found to be 35°C.

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