Date of Award


Degree Type


Degree Name

Master of Science in Pharmacology



First Advisor

David R. DeFanti


The relationship between urinary dopamine levels, and arterial blood pressure was studied in male albino rats.

The experimental rats were subjected to a right nephrectomy and received a monoamine oxidase inhibitor, either tranylcypromine or pargyline.

The blood pressure of the group receiving tranylcypromine was elevated to approximately 120 mm Hg during the first two weeks. During weeks seven and eight the blood pressure was further elevated to approximately 130 mm Hg but dropped back gradually to 115 mm Hg for a net drop of 3 percent where it remained to the end of the study. The blood pressure of the pargyline group, as expected, dropped steadily from approximately 115 mm Hg to approximately 84 mm Hg for a net drop of 34 percent.

Dopamine was extracted from paired urine samples by alumina and measured by spectrophotofluorimetry. Dopamine levels (mean from paired urine samples) of the experimental animals receiving pargyline or tranylcypromine were approximately 6 ug/ml/24 hour urine sample and 5 ug/ml/24 hour urine sample. These were lower than the levels of the control groups.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.