Title
Applications of pHLIP Technology for Cancer Imaging and Therapy
Document Type
Article
Date of Original Version
7-1-2017
Abstract
Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membrane-associated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tumor cells. The pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of nanoparticles. Since acidosis is a hallmark of tumor development, progression, and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases for tumor diagnosis, imaging, and therapy.
Publication Title, e.g., Journal
Trends in Biotechnology
Volume
35
Issue
7
Citation/Publisher Attribution
Wyatt, Linden C., Jason S. Lewis, Oleg A. Andreev, Yana K. Reshetnyak, and Donald M. Engelman. "Applications of pHLIP Technology for Cancer Imaging and Therapy." Trends in Biotechnology 35, 7 (2017): 653-664. doi: 10.1016/j.tibtech.2017.03.014.