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Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-Low Insertion Peptide (pHLIP) conjugated to near infrared fluorescent dye. It was proved that tumor targeting is a pH-dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers.
Reshetnyak, Y. K. (2015). Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography.
Clinical Cancer Research, 21(20), 4502-4504. doi: 10.1158/1078-0432.CCR-15-1502
Available at: http://dx.doi.org/10.1158/1078-0432.CCR-15-1502