Thioridazine improves affective symptoms in schizophrenic patients
Document Type
Conference Proceeding
Date of Original Version
1-1-1993
Abstract
Consenting schizophrenic patients ranging in age from 18 to 63 years were withdrawn from antipsychotics for at least 1 week and randomly assigned to receive identical capsules of thioridazine (n = 13), molindone (n = 10), or haloperidol (n = 12) for a minimum of 6 weeks. Compared with the molindone- and haloperidol-treated patients, the thioridazine-treated patients were significantly improved over time as measured by Brief Psychiatric Rating Scale (BPRS) and Hamilton Rating Scale for Depression (HAM-D) total scores. Improvement in BPRS scores was due largely to improvement in symptoms of anxiety and depression. Subjects did not differ significantly on other measures, with the important exception of weight. On average, molindone patients lost 5 pounds over the 6 weeks of treatment, whereas thioridazine patients gained 6 pounds. Haloperidol-treated patients had no significant weight changes.
Publication Title, e.g., Journal
Psychopharmacology Bulletin
Volume
29
Issue
2
Citation/Publisher Attribution
Dufresne, R. L., Valentino, and D. J. Kass. "Thioridazine improves affective symptoms in schizophrenic patients." Psychopharmacology Bulletin 29, 2 (1993): 249-255. https://digitalcommons.uri.edu/php_facpubs/1538