Title

Weighing in: Emergent diabetes mellitus and second-generation antipsychotics

Document Type

Article

Date of Original Version

10-1-2007

Abstract

Of all the metabolic effects of some of the atypical second-generation antipsychotics, their potential to induce glucose dysregulation has induced a storm of controversy over the past several years. The numerous published epidemiologic studies are difficult to interpret due to the high background rate of type 2 diabetes mellitus in this population, the inherent problems with analysis of observational data, and the short duration of the available studies. A plan to monitor for weight gain, hypertriglyceridemia, glucose dysregulation, and other potential adverse metabolic effects resulting from antipsychotic treatment is critical.

Publication Title

Annals of Pharmacotherapy

Volume

41

Issue

10

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