Title

Clozapine-associated elevation in serum triglycerides

Document Type

Article

Date of Original Version

8-1-1999

Abstract

Objective: This study was conducted to determine serum lipid level changes in patients who received clozapine or haloperidol. Method: Medical records of 222 inpatients treated with clozapine or haloperidol were reviewed. Age, weight, gender, daily antipsychotic dose, total cholesterol level, serum triglyceride level, and concurrent medications were recorded. Results: Clozapine-treated men had significantly higher follow-up serum triglyceride concentrations over baseline than did haloperidol-treated men. Female patients experienced serum triglyceride level elevations regardless of antipsychotic treatment. Changes in total cholesterol levels were not significantly different between treatment groups. Conclusions: An increase in serum triglyceride levels occurred in clozapine-treated patients; screening for serum triglyceride elevations may be warranted before treatment with clozapine.

Publication Title

American Journal of Psychiatry

Volume

156

Issue

8

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