The biosynthesis of astaxanthin. XVII. Intermediates in the conversion of β-carotene
Date of Original Version
1. 1. β-Carotene was fed to depleted goldfish at the levels of 2 mg. and 10 mg. per g. of food at different time intervals. 2. 2. The administration of β-carotene at 2 mg. per g. of food increased the astaxanthin content of the fish more than fourfold. 3. 3. In addition, isocryptoxanthin, isozeaxanthin, echinenone, and 4-hydroxy-4'-keto-β-carotene were synthesized. 4. 4. These pigments were undoubtedly metabolic products of β-carotene. They were not detected in the depleted fish and they disappeared when the fish fed with β-carotene for 6 days were returned to the non-carotenoid diet for 4 days. 5. 5. Increasing the β-carotene supplement to 10 mg. per g. of food raised the isocryptoxanthin and echinenone concentrations markedly. 6. 6. The data obtained proved that β-carotene is converted by the goldfish to astaxanthin through isocryptoxamhin, isozeaxanthin, echinenone, 4-hydroxy-4'-keto-β-carotene, and possibly canthaxanthin and phoenicoxanthin. © 1973.
International Journal of Biochemistry
Rodriguez, Delia B., K. L. Simpson, and C. O. Chichester. "The biosynthesis of astaxanthin. XVII. Intermediates in the conversion of β-carotene." International Journal of Biochemistry 4, 21 (1973): 213-222. doi:10.1016/0020-711X(73)90042-6.