Date of Original Version
The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
McGrath, B. J., Marchbanks, C. R., Gilbert, D., Dudley, M. N. (1993). In Vitro Postantibiotic Effect Following Repeated Exposure to Imipenem, Temafloxacin, and Tobramycin. Antimicrob. Agents Chemother., 37(8), 1723-1725. doi: 10.1128/AAC.37.8.1723.
Available at: http://dx.doi.org/10.1128/AAC.37.8.1723