Date of Original Version
Objective: Gold nanoparticles (GNPs) have the potential to enhance the effects of radiation therapy, using Auger electrons to cause additional damage to tumors. In this work, we explore the effect of two clinically important variables: dose fractionation and radiation energy. In clinical radiation therapy, radiation is fractionated (split into multiple sessions) and high-energy radiation is used. However, in the field of GNP research, radiation has generally been given in one session and lower radiation energies have generally been used.
Methods: Mice with JC breast tumors implanted in the flank were given radiation therapy over 1, 2, or 4 fractions, with radiation energies of either 250 kilovolts peak or 350 kilovolts peak. A survival analysis and a weighted generalized estimating equation analysis were used to.
Results: The use of multiple radiation fractions (between 1 and 4) and the use of radiation doses between 250-350 kVp were only different by statistically insignificant amounts, after the contributions from time, sex, age at irradiation and original tumor volume were accounted for. A survival analysis found a higher likelihood of death for female mice, mice given 350 kilovolts peak radiation (versus 250 kilovolts peak), and mice with larger tumors, as well as a lower likelihood of death for mice irradiated at an older age; fractionated radiation did not have a statistically significant effect.
Conclusion: These results suggest that GNPs have the potential to enhance radiation therapy when used with fractionated radiation.
Sah B, Wu J, Vanasse A, Antosh MP. Effect of radiation dose fractionation and radiation energy on gold nanoparticle enhancement of radiation therapy. J Nanomed. 2020; 3(1): 1016. https://meddocsonline.org/journal-of-nanomedicine/effect-of-radiation-dose-fractionation-and-radiation-energy-on-gold-nanoparticle-enhancement.pdf
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