Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
Date of Original Version
Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines. © 2011 Macmillan Publishers Limited. All rights reserved.
Publication Title, e.g., Journal
Nature Reviews Immunology
Rothman, Alan L.. "Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms." Nature Reviews Immunology 11, 8 (2011). doi: 10.1038/nri3014.