Immunoinformatic discovery of potential cross-reactive T cell epitopes in the measles genome
Date of Original Version
T cells are key mediators of inflammatory processes that can be activated by pathogens and vaccines. Some vaccine antigens may encode T cell epitopes that can cross-react with either human or human microbiome epitopes, causing deviation of the T cell response, leading to beneficial or, possibly, detrimental effects. An immune response shift attributed to cross-reactive T memory cells is known as heterologous immunity. Identification of T cell epitopes contained in pathogens and their vaccines and comparison of these epitopes against human and microbial genomic datasets are important steps to ensure that adaptive immune responses elicited by a vaccine are both pathogenspecific and protective, but not cross-reactive against host or hostassociated epitopes. Here, we use immunoinformatic methods to identify putative HLA A2-restricted measles vaccine epitopes that are cross-conserved with autologous proteins and with commensal microbiota. 45% and 63% of putative epitopes identified within the measles genome share significant homology to the human genome and a subset of genomes of the human microbiome, respectively. This important new information suggests there is significant potential for T cell cross-reactivity that will require experimental confirmation. Copyright © 2011 ACM.
Publication Title, e.g., Journal
2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, BCB 2011
Moise, Lenny, Eric Gustafson, Matthew Ardito, Alan Rothman, William Martin, and Anne S. De Groot. "Immunoinformatic discovery of potential cross-reactive T cell epitopes in the measles genome." 2011 ACM Conference on Bioinformatics, Computational Biology and Biomedicine, BCB 2011 (2011): 589-593. doi: 10.1145/2147805.2147906.