FANCP/SLX4: A Swiss army knife of DNA interstrand crosslink repair
Document Type
Article
Date of Original Version
6-1-2011
Abstract
Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair. © 2011 Landes Bioscience.
Publication Title, e.g., Journal
Cell Cycle
Volume
10
Issue
11
Citation/Publisher Attribution
Cybulski, Kelly E., and Niall G. Howlett. "FANCP/SLX4: A Swiss army knife of DNA interstrand crosslink repair." Cell Cycle 10, 11 (2011): 1757-1763. doi: 10.4161/cc.10.11.15818.