Translational potential for hydrogel composites containing carbon nanobrushes
Date of Original Version
The objective of this work is to examine potential translational directions for electrically conductive hydrogel composites as a matrix for clinically relevant cell lines. The composite is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to support the growth of fibroblasts and myocytes and eventually serve as a matrix to stimulate wound closure. In such a model, fibroblasts and myocytes are seeded on the hydrogel and bathed in culture medium. The experimental model assesses the ability of fibroblasts and myocytes to grow into and adhere to the gel. The work demonstrates that carbon nanobrushes can be dispersed within poloxamer gels, and that fibroblasts and myocytes can proliferate within homogenously dispersed carbon nanobrush-containing poloxamer gels. Future work will examine the effects of design parameters such as carbon nanobrush content and matrix structure on wound healing, as well as the growth of tendons and other cell lines within the hydrogel composites. This work has relevance for tissue engineering and tissue regeneration in clinical medicine. © 2012 IEEE.
Publication Title, e.g., Journal
2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Marks, William H., Sze C. Yang, George W. Dombi, and Sujata K. Bhatia. "Translational potential for hydrogel composites containing carbon nanobrushes." 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (2012). doi: 10.1109/NEBC.2012.6207129.