Date of Original Version
The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes and furans has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 minutes at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.
Sirois, J. J., Davis, R., & DeBoef, B. (2014). Iron-Catalyzed Arylation of Heterocycles via Directed C–H Bond Activation. Organic Letters, 16(3), 868-871. doi: 10.1021/ol403634b.