Convenient syntheses of 2,2'-biindole

Authors

Darrell J. Koza, University of Rhode Island
William B. Euler, University of Rhode Island

Document Type

Article

Date of Original Version

1-1-1999

Abstract

Two new syntheses for 2,2'-biindoles are reported. The first uses a palladium catalyzed annulation of a bis(o-iodophenyl)-α,β-diimine. The method employs mild conditions, gives good yields, and is potentially tolerant of a variety of substituent groups. The second method uses a Wittig reaction between a 2-nitrobenzylphosphonium salt and 2-nitrocinnamaldehyde to form 1,4-bis(2-nitrophenyl)butadiene, which followed by triethylphosphite cyclization to give the biindole.

Publication Title, e.g., Journal

Heterocyclic Communications

Volume

5

Issue

5

Citation/Publisher Attribution

Koza, Darrell J., and William B. Euler. "Convenient syntheses of 2,2'-biindole." Heterocyclic Communications 5, 5 (1999): 399-402. doi: 10.1515/HC.1999.5.5.399.

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.