Title

Increasing synthetic efficiency via direct C–H functionalization: Formal synthesis of an inhibitor of botulinum neurotoxin

Document Type

Article

Date of Original Version

4-4-2011

Abstract

A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C–H functionalization reactions, formally activating three C–H bonds. © 2011 The Royal Society of Chemistry.

Publication Title

Chemical Communications

Volume

47

Issue

16

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