Rhodium-catalyzed synthesis of eight-membered rings
Date of Original Version
(Chemical Equation Presented) Experiments to develop a rhodium catalyst for the [4 + 2 + 2] cycloisomerization of dienynes with a second alkyne are described. The generality of the reaction is probed in terms of dienyne structure and alkyne structure. A catalyst system that provides cyclooctatrienes in greater than 70% yield is reported. Several experiments to determine the nature of the catalyst are described. © 2007 American Chemical Society.
Journal of Organic Chemistry
DeBoef, Brenton, W. Richard Counts, and Scott R. Gilbertson. "Rhodium-catalyzed synthesis of eight-membered rings." Journal of Organic Chemistry 72, 3 (2007): 799-804. doi:10.1021/jo0620462.