Title

Rhodium-catalyzed synthesis of eight-membered rings

Document Type

Article

Date of Original Version

2-2-2007

Abstract

(Chemical Equation Presented) Experiments to develop a rhodium catalyst for the [4 + 2 + 2] cycloisomerization of dienynes with a second alkyne are described. The generality of the reaction is probed in terms of dienyne structure and alkyne structure. A catalyst system that provides cyclooctatrienes in greater than 70% yield is reported. Several experiments to determine the nature of the catalyst are described. © 2007 American Chemical Society.

Publication Title

Journal of Organic Chemistry

Volume

72

Issue

3

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