Cyclodextrin-Based Contrast Agents for Medical Imaging

Yurii Shepelytskyi, Lakehead University
Camryn J. Newman, Lakehead University
Vira Grynko, Lakehead University
Lauren E. Seveney, University of Rhode Island
Brenton DeBoef, University of Rhode Island
Francis T. Hane, Thunder Bay Regional Research Institute
Mitchell S. Albert, Thunder Bay Regional Research Institute


Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides consisting of multiple glucose subunits. CDs are widely used in host-guest chemistry and biochemistry due to their structural advantages, biocompatibility, and ability to form inclusion complexes. Recently, CDs have become of high interest in the field of medical imaging as a potential scaffold for the development of a large variety of the contrast agents suitable for magnetic resonance imaging, ultrasound imaging, photoacoustic imaging, positron emission tomography, single photon emission computed tomography, and computed tomography. The aim of this review is to summarize and highlight the achievements in the field of cyclodextrin-based contrast agents for medical imaging.