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A decacationic water-soluble pillararene possessing a nonsolvated hydrophobic core has been designed and synthesized. This supramolecular host is capable of binding xenon, as evidenced by hyperCEST depletion experiments. Fluorescence-based studies also demonstrate that xenon binds into the cavity of the pillararene with an association constant of 4.6 × 103 M−1. These data indicate that the water-soluble pillararene is a potential scaffold for building contrast agents that can be detected by xenon-129 magnetic resonance imaging.
Fernando, P. U. A. I., et al. (2020) Decacationic Pillararene: A New Scaffold for the Development of 129Xe MRI Imaging Agents. ACS Omega https://doi.org/10.1021/acsomega.0c02565
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