Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling
Date of Original Version
Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif.
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Pereira, K. C., Porter, A. L., & DeBoef, B. (2014). Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling. Tetrahedron Letters, 55(10), 1729-1732. doi: 10.1016/j.tetlet.2014.01.103
Available at: https://doi.org/10.1016/j.tetlet.2014.01.103
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