Magnetoliposome-integrated hydrogels for delayed and triggered deliveries
Date of Original Version
Statement of Purpose: Bone regeneration requires a sequence of events that can be regulated through the delivery of signaling factors. However, the optimal timings of these deliveries are not known and likely need to be customized for different patients and injuries. Therefore, there is an urgent need for biomaterial scaffolds that can flexibly control the timing and sequence of these factors. We hypothesize that delaying the delivery a differentiation factor can enhance osteo-differentiation and that a scaffold system can be developed to achieve delayed deliveries by integrating magnetoliposomes (MLs) into hydrogel matrices. Critically, MLs have previously been shown to release encapsulated payloads when remotely stimulated with radiofrequency (RF) magnetic fields.
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Madani, S. Zahra M., Anne Reisch, Emily Hughes, Geoffrey D. Bothun, and Stephen M. Kennedy. "Magnetoliposome-integrated hydrogels for delayed and triggered deliveries." Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium 40, (2019): 192. https://digitalcommons.uri.edu/che_facpubs/539