Title
Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia
Document Type
Article
Date of Original Version
7-1-2021
Abstract
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease.
Publication Title
Journal of Molecular and Cellular Cardiology
Volume
156
Citation/Publisher Attribution
Hamilton, Shanna, Radmila Terentyeva, Richard T. Clements, Andriy E. Belevych, and Dmitry Terentyev. "Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia." Journal of Molecular and Cellular Cardiology 156, (2021): 105-113. doi:10.1016/j.yjmcc.2021.04.002.