Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia
Date of Original Version
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease.
Journal of Molecular and Cellular Cardiology
Hamilton, Shanna, Radmila Terentyeva, Richard T. Clements, Andriy E. Belevych, and Dmitry Terentyev. "Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia." Journal of Molecular and Cellular Cardiology 156, (2021): 105-113. doi:10.1016/j.yjmcc.2021.04.002.