Title

Structures of 2-acetylaminofluorene modified DNA revisited: Insight into conformational heterogeneity

Document Type

Article

Date of Original Version

11-15-2010

Abstract

Despite the extensive data on dG-AAF, the major DNA adduct derived from the model carcinogen 2-acetylaminofluorene, little is known with respect to its solution structures. Here, we provide NMR/CD evidence for three conformers of dG-AAF in duplex DNA: major groove B-type (B), base-displaced stacked (S), and minor groove wedge (W). The S/B/W-conformational heterogeneities were found to be sensitive to the nature of the flanking DNA sequence contexts and pH. © 2010 American Chemical Society.

Publication Title

Chemical Research in Toxicology

Volume

23

Issue

11

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