Structures of 2-acetylaminofluorene modified DNA revisited: Insight into conformational heterogeneity
Date of Original Version
Despite the extensive data on dG-AAF, the major DNA adduct derived from the model carcinogen 2-acetylaminofluorene, little is known with respect to its solution structures. Here, we provide NMR/CD evidence for three conformers of dG-AAF in duplex DNA: major groove B-type (B), base-displaced stacked (S), and minor groove wedge (W). The S/B/W-conformational heterogeneities were found to be sensitive to the nature of the flanking DNA sequence contexts and pH. © 2010 American Chemical Society.
Publication Title, e.g., Journal
Chemical Research in Toxicology
Patnaik, Satyakam, and Bongsup P. Cho. "Structures of 2-acetylaminofluorene modified DNA revisited: Insight into conformational heterogeneity." Chemical Research in Toxicology 23, 11 (2010): 1650-1652. doi: 10.1021/tx100341u.