Date of Award


Degree Type


Degree Name

Master of Science (MS)


Pharmaceutical Sciences

First Advisor

John J. DeFeo


The trans-2-o-tolyl, trans-2-p-tolyl and cis-2-p-tolyl derivatives of cyclohexamine hydrochloride and six other cyclohexane derivatives were tested for their effects on intact anesthetized rats, isolated rat atria, isolated guinea pig hearts, isolated guinea pig intestines and intact anesthetized cats. Most of these compounds produced effects on the cardiovascular system and on the small intestine in varying degrees.

Trans-2-o-tolylcyclohexamine hydrochloride was the most potent of the cyclohexamine series tested. Of the six other compounds tested, 2-o-tolylcyclohexen-2-one ($204) was the most potent in its cardiovascular effects.

Studies indicate that trans-2-o-tolylcyclohexylamine hydrochloride does not produce toxic effects in doses which ellicit its cardiovascular actions.