Date of Award


Degree Type


Degree Name

Master of Science in Pharmaceutical Sciences




Pharmaceutical Sciences

First Advisor

Christopher T. Rhodes


The United States Pharmacopeia I National Formulary (USP/NF) sets the standards and maintains monographs for the evaluation of various dosage forms, especially during the storage and distribution channels. This document is compiled with the critical review of the stability testing of pharmaceutical products. In particular, it considers the progress toward globalization and harmonization, attention being directed to monitoring stability in the distribution channels. It is also focussed on the implications of Mean Kinetic Tempearature (MKT) concept and the effect of temperature spikes on MKT values, thus effecting the stability of drug products. The assignment of conformance period to the tablets were determined using the NIR stability indicating assay, both with the original data and the normalized. The stability of compounded cefazolin ophthalmic solution was studied for the various Arrhenius parameters and Beyond-use date assignment.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.