Date of Award


Degree Type


Degree Name

Master of Science in Pharmacology



First Advisor

John J. DeFeo


Derivatives of cyclohexanol were screened for pharmacological effects on intact anesthetized rats, isolated guinea pig heart, isolated rat atria and isolated rabbit small intestine. All the compounds tested produced a hypotensive response and cardio-inhibitory effects varying from slight depression to complete arrest. On the basis of recovery from induced cardiac arrest none of the compounds appeared to be cardio-toxic. All the compounds produced inhibitory effects on the isolated small intestine in varying degrees. Methyl 3-hydroxy-2-o-tolylcyclohexylacetate and trans-3-oxo-2-o-tolylcyclohexylacetic acid were equally potent and the most effective in their cardiovascular effects whereas the ketal from glycerol and 2-o-tolylcyclohexylacetate was the most effective on the isolated rabbit small intestine. Studies of mechanism, employing the isolated rat atria, indicate an antagonistic effect between these compounds and calcium.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.